Radiotherapy is an essential treatment for many patients affected by cancer1. As with most treatments used in the fight against cancer, radiotherapy comes with several acute and chronic side effects2. One of the most common side effects is radiation-induced skin reactions (RISR), which can affect up to 95% of patients treated with radiotherapy3. The development of RISR can begin at the start of treatment and increase in severity during and even beyond treatment, lasting for a few weeks after the final fraction of radiotherapy treatment has been delivered.
Over the years, advances in radiotherapy technologies and therapy techniques have allowed skin-sparing methods of treatment to reduce the severity of RISR for many patients. The introduction of intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) were expected to have a detrimental impact on the efficacy/toxicity ratio but, instead,...
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