Neuroimaging features of non-ketotic hyperglycaemia

The metabolic mimic: neuroimaging features of non-ketotic hyperglycaemia – a radiographic case study with CT and MRI correlation

Published on September 9, 2026

Neuroimaging features of non-ketotic hyperglycaemia

Abstract


Non-ketotic hyperglycaemia (NKH) is an important metabolic mimic that may present with acute neurological symptoms such as confusion, focal deficits and seizures, often requiring computed tomography (CT) or magnetic resonance imaging (MRI) correlation to differentiate it from an acute intracranial pathology1–4. 


This case study describes a 79-year-old male presenting with progressive unilateral choreiform movements (small involuntary, irregular, purposeless and unpredictable movements that often resemble a fidget or twitch) and focal neurological deficits, initially raising suspicion of intracranial haemorrhage or acute stroke. 


Non-contrast CT demonstrated unilateral basal ganglia hyperattenuation, raising suspicion for NKH and prompting further evaluation with MRI. MRI demonstrated corresponding T1 hyperintensity within the left basal ganglia with associated multi-sequence signal changes, in keeping with NKH associated hemichorea2,3,5. 


Correlation with clinical history and biochemical confirmation of diabetes mellitus supported the diagnosis. Recognition of this imaging...

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